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KMID : 0811720060100050283
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Korean Journal of Physiology & Pharmacology
2006 Volume.10 No. 5 p.283 ~ p.288
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Increased Rate of Palmitate Oxidation in Adults Female: Comparison with Peri-pubertal Young Female Rats
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Lee Se-Young
Kim Jong-Yeon
Kim Yong-Woon
Park So-Young
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Abstract
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Although estrogen is known to play a role in fatty acid metabolism, it remains unclear whether fatty acid oxidation in mature female rats differs from fatty acid oxidation in peri-pubertal young rats. In this study, we measured fatty acid metabolism in the skeletal muscles and livers of 5 and 50 weeks old male and female rats. The rate of palmitate oxidation in the liver and gastrocnemius red in the 50-week-old female rats were elevated as compared to the 5-week-old females, whereas there were no differences in the male rats. The rate of palmitate oxidation in the gastrocnemius red was correlated inversely with intra-abdominal fat mass in the 5-week-old male and female rats, whereas the palmitate oxidation rate was positively correlated with fat mass in the liver and gastrocnemius red in the 50-week-old rats. HOMA-IR and plasma insulin levels were positively correlated with intra-abdominal fat mass in the pooled 50-week-old male and female rats, but this correlation was not apparent in 5-week-old rats. In summary, the rate of fatty acid oxidation measured in the middle-aged adult female rats was significantly higher than those measured in the peri-pubertal young female rats. This difference may be attributed to the influence of ovarian hormones.
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KEYWORD
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Female, Intra-abdominal fat mass, Palmitate oxidation rate, Skeletal muscle
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